Synthesis of 4H-pyrimido [2,1-b]benzothiazole derivatives of curcumin by using multicomponent reaction using substituted aromatic aldehyde, 2-aminobenzothiazole and curcumin has been carried out in the presence of Al-Pb-CO3hydrotalcite as a heterogeneous solid catalyst which is recyclable under solvent free condition. The hydrotalcite need short reaction time, non-toxic , reusable and easy to workup. Thus making this process environmentally friendly. 4H- pyrimido[2,1-b] benzothiazole derivatives of curcumin are potential molecules having good antibactaroal, anti-inflammatory, antimicrobial, and cancer preventive properties.
Keywords: Multicomponent synthesis, Al-Pb-CO3hydrotalcite , solvent free condition.
Rita Singh, D.D. Agarwal & M.C. Agarwal